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Horn-O Tablets

DETAILS
COMPOSITION

Each film-coated tablet contains Ofloxacin USP 200 mg and Ornidazole 500 mg.

INDICATIONS Moderate to severe systemic infection and GI infections such as acute diarrhoea/dysentery due to bacterial, protozoal or mixed origin, post operative infections, gynecological infections, lung infections, acute and chronic bone and joint infection specially of foot, infections in immunocompromised patients.
MODE OF ACTION Ofloxacin inhibits bacterial DNA-gyrase enzyme required for DNA replication and thus causes bacterial lysis. The antimicrobial activity of Ornidazole is due to the reduction of the nitro group to a more reactive amine that attacks the microbial DNA and destroys it.
ADVERSE EFFECT

Nausea, abdominal pain, epigastric discomfort, vomiting, pseudomembranous colitis, myalgia, arthralgia, bone marrow depression, vertigo, skin rash, headache.

CONTRAINDICATION

Hypersensitivity to Nitroimidazole derivatives or Quinolones, pregnancy and lactation.

SPECIAL PRECAUTIONS

Caution should be exercised in patients with diseases of the CNS, e.g., epilepsy or multiple sclerosis. A health risk exists, among others, in patients with liver disease, in alcoholics, epileptics, in patients with brain damage, renal dysfunction and exposure to sunlight, geriatric patients.

DRUG INTERACTION:

In contrast to other nitroimidazole derivatives, ordinazole does not inhibit aldehyde dehydrogenase and is therefore not incompatible with alcohol. However, ornidazole potentiates the effect of coumarin-type oral anticoagulants. The dosage of the anticoagulant has to be adjusted accordingly. Ornidazole prolongs the muscle-relaxant effect of vecuronium bromide.

Concomitant use of ofloxacin and anti-coagulants may increase the effect of the latter. Concomitant use of ofloxacin and theophylline may increase in theophylline steady state level although the clinical significance of this interaction is unclear. Concurrent use of ofloxacin and NSAID may lead to CNS excitation. Concurrent use of Ofloxacin and an Aluminium, Magnesium or Calcium containing antacid may result in decrease serum concentration of the antibiotic leading to loss of therapeutic efficacy. If the dose of Ofloxacin and antacid is separated by 2 hours the bioavailability of Ofloxacin is not decreased to a clinically significant extent. Administration of ferrous salt with Ofloxacin has been found to significantly reduce the absorption of Ofloxacin. Atleast 24 hours or more should be allowed between the administration of the last dose of Ofloxacin and the live Typhoid vaccine. Fluroquinolones are capable of forming chelate complexes with metal ions including Calcium and Zinc resulting in reduced bioavailability of the Quinolone antibiotic.
DOSES AND ADMINISTRATION

Adult: 1 tablet twice daily.

PACKING Strip of 6 tablets.

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