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Untitled Document
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 Medicines for
 Anti Diarrhoeal
Antimicrobial
Antidiabetic
Antacid/Anti peptic ulcerant
Laxative
Ophthalmological
Stomatological
Anitiinflammatory
Herbal
Others
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DETAILS
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| COMPOSITION |
Chlorhexidine Gluconate solution IP diluted to
Chlorhexidine Gluconate 0.2 % w/v |
| INDICATIONS |
Dental caries, Periodontitis, Gingivitis, Dentin hypersensitivity, Dental procedures/implants, Alveolar osteihs, Aphthuous ulcer. |
| MODE OF ACTION |
Chlorhexidine reduces plaque formation. Chemically, it is a polybiguanide with bactericidal activity. The drug is a base and is stable as a salt, the most common being chlorhexidine gluconate. At physiologic pH, chlorhexidine dissociates & releases a +vely charged component. This binds to the bacterial cell wall and extramicrobial complexes which is -vely charged. At low concentration, this causes an alteration of bacterial cell osmotic equilibrium & leakage of K+ & phosphorus resulting in a bacteriostatic effect. At high concentration, chlorhexidine makes the cytoplasmic content of the bacterial cell to precipitate resulting in cell death. |
| ADVERSE EFFECT |
Occasional reports of dulling of taste sensation for several hours. Tooth discoloration is the most common side-effect although cosmetic in nature. The amount of staining varies from one individual to another and on chlorhexidine concentration. |
| DOSAGE AND ADMINISTRATION: |
Chlorhexidine half ounce (15ml.) should be used for 30 sec after tooth brushing twice daily or as directed by the physician. Oral rinse should be expectorated, not swallowed. Swallowed chlorhexidine is eliminated via the faeces. |
| PACKING |
100 ml bottle. |
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Horn 